(NIH/National Institute of Mental Health) Scientists have synthesized a molecule with a unique profile of highly specific pain-relieving properties and demonstrated its efficacy in mice. PZM21 was not 'reinforcing' or prone to triggering respiratory impairment and was less constipating than existing analgesics. It had more effect on the brain-mediated emotional/experiential component of pain than on spinal cord reflexive responses. In addition to clinical potential, it holds promise as a 'tool molecule' for exploring the workings of brain pain systems.
from EurekAlert! - Social and Behavioral Science http://ift.tt/2b4GH4m
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