Small populations of normal cells affect immunity in patients with XLP1

(Tokyo Medical and Dental University) Patients with X-linked lymphoproliferative syndrome type 1 (XLP1) are at risk of fatal infectious mononucleosis. Here, a Tokyo Medical and Dental University (TMDU)-led research team performed detailed analyses of T cells in a family with a mild form of XLP1. They found small populations of CD4+ and CD8+ T cells expressing SLAM-associated protein at normal levels, suggesting that less invasive therapies, which affect fewer T cells, may be useful in treatment of XLP1.

from EurekAlert! - Social and Behavioral Science https://ift.tt/2Dw9ZcG