(Kanazawa University) Rats are used commonly in nonclinical drug-development studies (DDS). Miki Nakajima and colleagues at Kanazawa University (Kanazawa, Japan) quantified hepatic and intestinal mRNA expression of uridine 5'-diphospho-glucuronosyltransferase (Ugt) isoforms in rats. They revealed strain- and sex-based differences in expression of Ugts in rats. This study would be helpful for pharmaceutical scientists in choosing the strains and sex of rats for DDS.
from EurekAlert! - Social and Behavioral Science https://ift.tt/2GAGDeH
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