(Medical University of South Carolina) Patients with lupus are at increased risk of heart disease. Exposing endothelial cells -- known to protect against heart disease, in part by producing nitric oxide -- to the serum of patients with lupus decreased nitric oxide production. Administering L-sepiapterin restored that production. These findings, reported by Medical University of South Carolina researchers in Lupus Science & Medicine, provide proof-of-concept that the enzyme is a promising therapeutic target for heart disease in lupus and beyond.
from EurekAlert! - Social and Behavioral Science https://ift.tt/2CEEPh9
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